4-Acetaminophen/paracetamol for severe pain 103-90-2

4-Acetamidophenol / Paracetamol for severe pain 103-90-2What is Paracetamol ?Paracetamol, also known as acetaminophen and APAP, is a medication used to treat pain and fever. It is typically used for mild to moderate pain relief. There is mixed evidence for its use to relieve fever in children. It is often sold in combi

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4-Acetamidophenol / Paracetamol for severe pain 103-90-2


What is Paracetamol ?

Paracetamol, also known as acetaminophen and APAP, is a medication used to treat pain and fever. It is typically used for mild to moderate pain relief. There is mixed evidence for its use to relieve fever in children. It is often sold in combination with other medications, such as in many cold medications. Paracetamol is also used for severe pain, such as cancer pain and pain after surgery, in combination with pain medication.


Paracetamol Basic Information

Synonyms:4-Acetamidophenol;4-Acetaminophenol;4'-Hydroxyacetanilide;4-Hydroxyacetanilide;4-(Acetylamino)Phenol;Acetaminophen;Acetyl-p-Aminophenol
CAS:103-90-2
MF: C8H9NO2
MW:151.16
EINECS: 203-157-5
General Description:Odorless white crystalline solid. Bitter taste. pH (saturated aqueous solution) about 6.
MP: 168-172 °C(lit.)
Density:1,293 g/cm3
Water Solubility:14 g/L (20 ºC)
Air & Water Reactions:Slightly soluble in water.
Reactivity Profile:4-Acetamidophenol is sensitive to light. Incompatible with strong oxidizers. .
Fire Hazard:Flash point data for 4-Acetamidophenol are not available; however, 4-Acetamidophenol is probably combustible.
Biological Activity:  Cyclooxygenase inhibitor; may be selective for COX-3 (IC 50 values are 460, > 1000 and > 1000 μ M for canine COX-3, and murine COX-1 and COX-2 respectively). Widely used analgesic and antipyretic agent.

Paracetamol Uses

Analgesic; antipyretic. Dispersing agent in liquid scintillation counting.


Paracetamol specification
 
Items of analysisSpecificationResults
CharactersWhite crystalline powderComplies
IdentificationComplies with the test for Identification of paracetamolComplies
Chloride≤0.014%<0.014%
   
Sulfate≤0.02%<0.02%
Heavy metals≤0.001%<0.001%
Readily carboni-zable substance≤Matching fluid AComplies
Organic volatile impuritiesCompliesComplies
Residual solventsCompliesComplies
SulfidCompliesComplies
Related substance 4-chloroacetanildeCompliesComplies
Melting Point168ºC~172ºC169.4ºC~170.3ºC
4-Aminophenol≤0.005%<0.005%
Loss on drying≤0.5%0.04%
Residue on ignition≤0.1%0.06%
   
Assay99.0%~101.0%99.40%
ConclusionQualified


4-Acetamidophenol / Paracetamol for Severe Pain 103-90-2
 
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Pramipexole104632-26-0
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Tetramisole hydrochlorid5086-74-8
Paracetamol 103-90-2
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